ABSTRACT
In this paper, we propose a new mathematical model of cardiovascular system coupled with a respiratory system to study the effects of COVID-19 on global blood circulation parameters using the lumped parameters model. We use the fourth-order Runge-Kutta method for solving the sets of equations of motion. We validate our model by showing that the simulated flows in pulmonary and aortic valves corroborate, respectively, the results established by Smith et al. [IFAC Proceedings Volumes, 39 (2006) 453-458]. Then we examine the effects of the new coronavirus (covid-19) on the cardiopulmonary system through the impact of the high respiratory frequency and the variation of the alveoli volume. To achieve this aim, we propose a new exponential law for the time varying of the pulmonary resistance. It appears that when the respiratory frequency grows, the delay between the systemic artery flow and the flow in the pulmonary artery diminishes. Therefore, the efficiency of the cardiac pump is reduced. Moreover, our results also show that variations of the alveoli volume cause the increment of the pleural pressure in the vascular cavities that induces an exponential growth of the pulmonary resistance. Furthermore, this growth of the pulmonary resistance provokes the augmentation of pressure in some organs and its reduction in others. We found that patient with covid-19 having a prior history of cardiovascular diseases is exposed to a severe case of inflammation/damage of certain organs than those with no history of cardiovascular disease.
ABSTRACT
The new devastating pandemic coronavirus disease 2019 (COVID-19) caused by the novel coronavirus severe acute respiratory syndrome (SARS-CoV-2) has been related to approximately 600 million cases and more than six million deaths till now. After recovery from COVID-19, some patients develop long-term sequelae called long COVID (LC). LC cases have been reported with multi-system involvement, with the most common being neuro-psychiatric, cardiorespiratory, hematological, and gastrointestinal systems highlighting the need for multidisciplinary team involvement and treatment. Since we are more than two and half years into this pandemic, we have more understanding of the pathophysiology and successful treatment of acute COVID-19, and we see more survivors and, subsequently, individuals with LC. However, the pathogenic mechanisms leading to LC are not clear till now. This review describes the potential pathogenic mechanisms leading to LC and common clinical manifestations reported from current evidence. [ FROM AUTHOR]
ABSTRACT
Wearable technologies are essential for telehealth services and for reducing the load on the healthcare systems. The wearables enable individuals to personalize health monitoring out of hospitals and allow physicians to remotely assess the health status of individuals and track the recovery process. Here, we developed a multimodal wearable device to record breathing patterns and cough events with a low noise, wide dynamic range microelectromechanical accelerometer. In addition, the wearable device included a high-sensitivity pulse oximeter and heart rate to record blood oxygen saturation levels. The device recorded cough vibrations, oxygen saturation level and a respiratory profile that can be used for evaluation of the respiratory system. The device was tested on healthy volunteers and a subject with COVID-19 during quarantine. © COPYRIGHT SPIE. Downloading of the is permitted for personal use only.